Functions:

• converts estrogen into 4-hydroxy estrogen.
• partially responsible for detoxifying polycyclic aromatic hydrocarbons (PAHs), products of the burning of organic materials, like car exhaust, cigarette smoke and charbroiled foods.

Substrates - compounds metabolized by that enzyme. The metabolism of some of these compounds is shared by other P450 enzymes (see other P450 lists).

Inhibitors - may or may not be substrates of that enzyme, but will reliably reduce that enzyme's activity if they're present

Inducers - also may or may not be substrates, but will tend to increase the enzyme's activity.

Health Implications of CYP1B1 Polymorphism:

• 4-hydroxy estrogen that may contribute to estrogen-sensitive carcinogenicity

Minimizing Risk from CYP1B1 Polymorphism:

• Regular aerobic exercise is important.
• Make soy foods (tofu, tempeh and soy beans) and cold water fish (salmon, mackerel, etc.) a regular part of your diet.
• Do not smoke.
• Avoid charbroiled and well-done meats.
• Minimize exposure to car and diesel exhaust.
• Avoid contact with industrial solvents.
• Increase the 2-hydroxylation of estrogens:
  • lndol-3carbinol (13C) or diindolylmethane (DIM)
  • Fish oil (EPA/DHA)
• Down-regulate CYP1B1 induction and expression:
  • DHEA
  • Hesperidin (a flavonoid)
  • A daily glass of red wine may be beneficial (resveratrol)

For more information:

• CYPs 1A1 and 1B1 share some characteristics: see the Wikipedia stub for CYP1B1.