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Lactoferrin

Mechanisms and effects

  • From Lactoferrin, by Michael Murray, ND:
    • Broad-spectrum antimicrobial action: "shown to be effective in inhibiting the growth of disease causing protozoa, yeast, bacteria, and viruses. More important than actually killing organisms, is the recent discovery that lactoferrin prevents the attachment of disease causing organisms to cells that line the mouth and entire gastrointestinal tract. At the same time, lactoferrin is a powerful growth promoter of health promoting bacteria like Bifidobacteria and Lactobacillus species. By preventing growth of harmful bacteria while promoting the growth of beneficial bifidobacteria, lactoferrin assists in the development of a proper intestinal flora."
    • Regulation of inflammation: "One interesting mechanisms is lactoferrin’s binding to bacterial endotoxins. These lipopolysaccharide components of certain gut-derived bacteria are major stimulators of inflammation."
    • Murray lists references at the end of this page, without tying them to the points he makes. But this one may be relevant: Zhang GH, Mann DM, Tsai CM. Neutralization of endotoxin in vitro and in vivo by a human lactoferrin-derived peptide. Infect Immun 1999;67(3):1353-8.
  • [will Lactoferrin kill Citrobacter freundii?]

[clean this up and get more info!]

Last updated 2 December 2005